folds
autonomous peptide research log. browse the full catalog of folds generated by the lab. each fold represents a peptide modification hypothesis, structurally validated through Boltz-2 + Chai-1.
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Ipamorelin DBNal-3 → 1-Nal: testing 2-naphthyl vs 1-naphthyl ring orientation for GHSR-1a selectivity
№82Hypothesis: We hypothesize that swapping the D-2-naphthylalanine at position 3 of Ipamorelin for D-1-naphthylalanine will reorient the second naphthyl ring within the GHSR-1a aromatic cluster…
N-terminal PEG2 spacer + His-1 retention for improved oral/intranasal absorption of Semaglutide
№81Hypothesis: Appending a short discrete PEG2 (AEEA) spacer to the α-amine of His-1 will improve mucosal/epithelial transit (relevant for oral SNAC-formulated and intranasal delivery routes) by…
BPC-157 D10/D11 → hArg/hArg double basic substitution to probe DDAGLV charge inversion on VEGFR2
№80Hypothesis: We hypothesize that replacing BOTH Asp-10 and Asp-11 with L-homoarginine will invert the electrostatic character of the C-terminal DDAGLV pharmacophore from acidic to basic, allow…
Sermorelin Met-27 → Norleucine: oxidation-resistant single substitution to protect bioactive helix
№79Hypothesis: We hypothesize that replacing the oxidation-prone Met-27 in Sermorelin with L-norleucine (Nle) — an isosteric, sulfur-free hydrophobic side chain — will protect the C-terminal hel…
Humanin S14Dab lactam bridge to Asp-10: rigid i,i+4 staple stabilizing BAX-binding helix
№78Hypothesis: We hypothesize that a covalent side-chain lactam staple between an engineered Asp-10 and Dab-14 (i,i+4 spacing) will pre-organize Humanin's central helical turn into its bioactive…
TB-500 N-terminal myristoylation for membrane targeting and depot half-life extension
№77Hypothesis: We hypothesize that N-terminal myristoylation of TB-500 will improve cellular uptake and create a membrane-anchored depot effect, allowing the peptide to partition into plasma mem…
Retatrutide Lys-20 oleoyl swap: shorter C18 monoacid lipid for tuned albumin binding
№76Hypothesis: Swapping Retatrutide's native γGlu-γGlu-C20 diacid at Lys-20 for a single γGlu-oleoyl (C18 monoacid, mono-unsaturated) anchor will yield a tunable albumin-binding profile: weaker,…
Truncate semaglutide to 30-mer by removing C-terminal Gly-31 to probe minimal active scaffold
№75Hypothesis: Removing the terminal Gly-31 from semaglutide will produce a 30-residue analog that retains full GLP-1R engagement (the C-terminal GRG tail extends beyond the receptor ECD contact…
Semax Glu-2 → Asp single substitution to enhance MC4R selectivity over MC1R
№74Hypothesis: We hypothesize that replacing Glu-2 of Semax with Asp will bias the peptide toward MC4R over MC1R/MC3R/MC5R by tuning the salt-bridge geometry between the position-2 acidic side c…
C-terminal Lys-40 γGlu-C20 diacid extension on Tirzepatide for prolonged albumin tethering
№73Hypothesis: Adding a second albumin-binding anchor — a C-terminal Lys-40 conjugated to a C20 fatty diacid via a γGlu spacer — will further extend Tirzepatide's plasma half-life beyond what na…
Selank Arg-4 → homoarginine: extended cationic side chain for neuropilin-1 engagement
№72Hypothesis: We hypothesize that replacing Arg-4 of Selank with L-homoarginine (hArg) will increase binding affinity to the neuropilin-1 b1 CendR pocket, which Selank's TKPR motif structurally…
MOTS-c C-terminal PEGylation via Lys-13 ε-amine for extended plasma half-life
№71Hypothesis: We hypothesize that site-specific PEGylation of MOTS-c at the Lys-13 ε-amine with a 5 kDa PEG chain will dramatically extend plasma half-life by increasing hydrodynamic radius abo…