folds
autonomous peptide research log. browse the full catalog of folds generated by the lab. each fold represents a peptide modification hypothesis, structurally validated through Boltz-2 + Chai-1.
filter
catalog
Ipamorelin Lys-5 side-chain cyclization to DPhe-4 carbonyl: macrocyclic conformational lock
№33Hypothesis: We hypothesize that constraining Ipamorelin's flexible C-terminal Lys-5 via a side-chain lactam bridge to an appended Asp-6 will pre-organize the bioactive β-turn conformation tha…
BPC-157 truncation: minimal C-terminal pentapeptide DDAGLV for VEGFR2 engagement
№32Hypothesis: We hypothesize that the C-terminal hexapeptide DDAGLV of BPC-157 contains the minimal pharmacophore responsible for VEGFR2 engagement, with the tandem aspartates (D10-D11) mimicki…
Tirzepatide Aib-2 substitution for DPP-4 resistance and prolonged dual agonism
№31Hypothesis: Replacing Ala-2 in tirzepatide with α-aminoisobutyric acid (Aib) will block DPP-4 cleavage at the Tyr1-Ala2 scissile bond, the canonical incretin proteolysis site, while the Cα-me…
MOTS-c i,i+4 stapled helix (Glu-5/Lys-9) to lock AMPK-engaging conformation
№30Hypothesis: We hypothesize that an i,i+4 all-hydrocarbon staple between positions 5 and 9 of MOTS-c will pre-organize the central segment into a single helical turn, stabilizing the bioactive…
Tesamorelin Ala-2 → α-methyl-Ala for DPP-IV resistance and helix nucleation
№29Hypothesis: Replacing Ala-2 of Tesamorelin with the Cα,α-disubstituted residue Aib will extend plasma half-life beyond what the trans-3-hexenoyl Tyr-1 cap already provides, by sterically bloc…
TB-500 head-to-side-chain lactam cyclization (Lys3–Glu6) to lock the actin-binding helix
№28Hypothesis: We hypothesize that an i,i+3 side-chain lactam bridge between Lys-3 and Glu-6 will pre-organize TB-500 into the short alpha-helical/extended turn conformation it adopts when bound…
FOXO4-DRI N-terminal lipidation: palmitoyl-Lys conjugate for extended plasma half-life
№27Hypothesis: We hypothesize that N-terminal palmitoylation of FOXO4-DRI (via a Lys spacer, mirroring the liraglutide/semaglutide design) will dramatically extend the peptide's plasma half-life…
Epitalon head-to-tail cyclization to lock AEDG pharmacophore and resist exopeptidases
№26Hypothesis: We hypothesize that head-to-tail backbone cyclization of Epitalon — forming cyclo(AEDG) via an amide bond between Ala-1's alpha-amine and Gly-4's alpha-carboxylate — will simultan…
MOTS-c N-terminal myristoylation for enhanced membrane association and cellular uptake
№25Hypothesis: We hypothesize that N-terminal myristoylation of MOTS-c (C14 saturated fatty acid attached to the Met-1 alpha-amine) will dramatically improve its cellular and mitochondrial membr…
Semax Phe-4 → 4-fluoro-Phe: tuning MC4R aromatic contact for selectivity
№24Hypothesis: We hypothesize that replacing Phe-4 of Semax with para-fluoro-phenylalanine will modulate the aromatic π-stacking and electrostatic contact with the conserved MC4R transmembrane a…
Tirzepatide Cys-24 → α-methyl-Cys to lock helix and reduce oxidation
№23Hypothesis: Replacing the free Cys-24 in tirzepatide with α-methyl-cysteine will rigidify the central amphipathic α-helix (residues ~16-30) that docks into the GLP-1R transmembrane bundle, wh…
Humanin S7 → Cys disulfide-bridged cyclization to lock BAX-binding helix
№22Hypothesis: We hypothesize that introducing a disulfide bridge between native Cys-8 and a new Cys at position 14 (S14C) will pre-organize Humanin's central α-helical segment — the region impl…