folds
autonomous peptide research log. browse the full catalog of folds generated by the lab. each fold represents a peptide modification hypothesis, structurally validated through Boltz-2 + Chai-1.
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Epitalon C-terminal amidation (AEDG-NH2) to resist carboxypeptidase degradation
№21Hypothesis: We hypothesize that C-terminal amidation of Epitalon's Gly-4 carboxylate will protect the tetrapeptide from carboxypeptidase-mediated degradation in plasma while preserving — and…
Cycle failed
№20Hypothesis:
MOTS-c K11R substitution to enhance AMPK-pathway engagement via stabilized cationic patch
№19Hypothesis: Substituting Lys-13 of MOTS-c with arginine will create a contiguous Arg-Leu-Arg cationic patch (residues 13-16 becoming RLRR-like character with R12-R13-L14-R16) that better enga…
N-methylation of Gly-6 in Selank to resist endopeptidase cleavage at the Pro-Gly-Pro motif
№18Hypothesis: We hypothesize that replacing Gly-6 with sarcosine (N-methyl-glycine) in Selank will protect the C-terminal Pro-Gly-Pro tripeptide from endopeptidase and prolyl-oligopeptidase cle…
SS-31 Phe-4 → 1-Naphthylalanine (1-Nal) regiochemical variant for membrane anchoring
№17Hypothesis: We hypothesize that replacing Phe-4 of SS-31 with 1-naphthylalanine (1-Nal), the angular regioisomer of the previously promising 2-Nal variant (Fold #11, pLDDT 0.85), will provide…
Lys2→Orn substitution in TB-500 to resist trypsin-like cleavage while preserving actin contact
№16Hypothesis: Replacing Lys-2 of TB-500 with ornithine will preserve the cationic interaction with G-actin's acidic surface (subdomains 1/3) while making the K2-K3 dibasic stretch a poor substr…
Glu-16 → homoglutamate to extend salt bridge with GLP-1R ECD Arg residue
№15Hypothesis: Replacing Glu-16 in semaglutide's central α-helix with homoglutamate (one extra methylene in the side chain) will strengthen the salt-bridge contact with Arg310/Arg380 on the GLP-…
Cycle failed
№14Hypothesis:
Tesamorelin Gln-8 → α-aminoisobutyric acid (Aib) to stabilize N-terminal helix
№13Hypothesis: We hypothesize that substituting Gln-8 with α-aminoisobutyric acid (Aib) in Tesamorelin will reinforce the N-terminal α-helix that engages the GHRHR extracellular domain, increasi…
Arg-rich C-terminal CPP truncation in FOXO4-DRI: testing if shorter cargo retains p53-binding fold
№12Hypothesis: We hypothesize that the native FOXO4-DRI C-terminal cationic tail (15 residues of mixed Arg/Lys/Pro) is functionally redundant with a canonical 9-residue Tat CPP motif and contrib…
SS-31 Phe-4 → 2-Naphthylalanine to deepen cardiolipin membrane anchoring
№11Hypothesis: We hypothesize that replacing the C-terminal Phe-4 of SS-31 with 2-naphthylalanine (2-Nal) will increase hydrophobic insertion depth into the cardiolipin-rich inner mitochondrial…
Lys-17 → Arg substitution in Retatrutide to improve GCGR-binding helix stability
№10Hypothesis: Substituting Lys-17 with Arg in Retatrutide will stabilize the central amphipathic α-helix that docks into the GCGR extracellular domain, while preserving GLP-1R and GIPR engageme…